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General patient information:
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Uterine Fibroids Their Symptoms and Treatment
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Uterine Fibroid Embolization at UAB
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Fibroid embolization at UAB is a multi-step process. You or your doctor can contact Interventional Radiology at UAB by calling 205-934-0152. The scheduling nurse will briefly discuss the procedure with you and get your contact information. We will then send you a letter and a patient information brochure with more information.
If you decide to proceed, we ask that you have your physician send us a copy of your medical records. This is often the slowest step and we encourage you to be proactive in requesting these from your physician. You must have been evaluated by a gynecologist within 6 months of your visit. If you do not have a gynecologist, a referral can be provided.
Once we receive your medical records, an MRI (Magnetic Resonance Imaging) exam of your pelvis will be scheduled. This is a non-invasive test that does not use radiation like other types of X-rays. An intravenous line will be started to give dye for the test as this helps us evaluate your fibroids better. The i.v. is removed as soon as the exam is completed. Even if you have already had an ultrasound to diagnose fibroids, we ask that you get an MRI as we have found that this is the most reliable way to diagnose and evaluate fibroids. We will follow the decrease in fibroid size after the procedure with MRI imaging.
You will then be scheduled for a consult visit with an Interventional Radiologist. (Directions to UAB) At this visit he or she will sit down with you, review your history and MRI, and do a brief physical exam. She will discuss the procedure with you, including the benefits and risks to you of fibroid embolization. Some patients are not candidates for fibroid embolization and if not, other medical and surgical options will be discussed and referrals provided if necessary. If you wish to proceed, you can schedule your procedure. Insurance coverage will be confirmed at this time and you will be notified if there are any problems.
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The morning of the procedure, you will report to the 6th floor of Jefferson Towers at UAB and be taken to our Same Day Surgery area. We ask that you not eat or drink after midnight the day before your procedure. Also, you may wish to shave your groin area at home as it will be done at the time of procedure otherwise. You will be asked to change into a hospital gown and an intravenous (i.v.) line started. Appropriate blood work including a pregnancy test will be sent. A Foley catheter will be placed in your bladder. We need to place a catheter in your bladder, so that the bladder will remain empty during the procedure. Since the bladder is directly in front of the uterus, it is important that it does not fill during the procedure or it would obscure our view.
Once you are ready, you will be taken to the Interventional Radiology pre-procedure area. Your procedure will take approximately 1-2 hours once we begin. You will be given conscious sedation and will be sleepy, but not under general anesthesia. Most patients sleep comfortably throughout the exam. After the procedure, you will be given pain medicine through your i.v. and sent to a room. You will be on strict bed rest for 6 hours after the procedure. You will stay in the hospital overnight. The morning after the procedure, your Foley catheter will be removed and you will be started on oral pain medication as needed. Most patients go home the next day around lunch time. You will receive a sheet of written discharge instructions and an appointment for a follow-up visit and MRI in 6 months. The Interventional Radiology staff will follow-up with you by phone in your first days and weeks home, and we encourage you to call us with any questions or concerns. See pictures below of a typical fibroid embolization.
Many patients will experience moderate to severe crampy abdominal pain and nausea the first day. This usually substantially improves after the first 12-24 hours. Most patients will have some continued crampy abdominal pain and discharge for the first 1-2 weeks after the procedure. By two weeks post procedure the majority of patients are able to go back to work and resume normal activities.
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Some of the information contained on this website is provided in whole or in part by the Society of Interventional Radiology(c) 2004, www.SIRweb.org, and is reprinted with their permission. |
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A typical fibroid embolization.... |
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| Fig. 1 Patients waiting in pre-procedure holding area. |
Fig. 2 Patient undergoing fibroid embolization. |
Fig. 3 Dr. Rachel Oser and a UAB Resident performing a Uterine Fibroid Embolization. |
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Fig. 4 Image from MRI exam showing fibroid in the uterus before embolization.
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Fig. 5 Arteriogram of left uterine artery before embolization.
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Fig. 6 Arteriogram of left uterine artery after embolization.
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Fig. 7 MRI of uterus 6 months after embolization showing dramatic reduction in size of fibroids.
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Interventional Radiology at UAB
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Interventional Radiology at UAB is a division of the UAB Department of Radiology. There are two full time Interventional Radiologists (Drs.Rachel Oser and Souheil Saddekni) and one part time Interventional Radiologist at UAB (Dr. Sameer Bhatia). The UAB section of vascular and interventional radiology also employs a physicians assistant, a nurse practioner and multiple registered nurses and radiology technologists who will participate in your care. UAB is a teaching hospital with residents and fellows. Currently Dr. Rachel Oser is accepting patients for uterine fibroid embolization. |
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What is Interventional Radiology? |
Who are interventional radiologists? |
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Interventional radiologists (IRs) use their expertise in reading X-rays, ultrasound and other medical images to guide small instruments such as catheters (tubes that measure just a few millimeters in diameter) through the blood vessels or other pathways to treat disease percutaneously (through the skin). These procedures are typically much less invasive and much less costly than traditional surgery. |
Interventional radiologists are medical doctors who have specialized in doing medical procedures that involve radiology. Radiologists use imaging equipment such as X-rays, magnetic resonance (MR) imaging, ultrasound and computed tomography (CT) to diagnose disease. IRs are board certified radiologists that are fellowship trained in percutaneous interventions using guided imaging. Their specialized training is certified by the America Board of Medical Specialties. |
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How did interventional radiology develop? |
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The improved ability of radiologists to see inside the body gave rise to interventional radiology -- minimally invasive targeted treatments performed using imaging for guidance -- in the mid-1970's. Interventional radiologists invented angioplasty and the first catheter-delivered stent, what was first used in the legs, to save patients with vascular disease from amputation or other surgery. These advances pioneered modern medicine and gave rise to the state-of-the-art treatments that are common place today. Interventional radiology is a medical specialty recognized by the American Board of Medical Specialties and the American Medical Association.
Today there are more than 5,000 interventional radiologists in the United States. The Society of Interventional Radiology (SIR), the professional association of interventional radiologists based in Fairfax, VA, has seen its membership steadily increase to more than 4,000 worldwide in 2004.
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What are the advantages of interventional radiology? |
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Most procedures can be performed on an outpatient basis or require only a short hospital stay.
General anesthesia usually is not required.
Risk, pain and recovery time are often significantly reduced.
The procedures are sometimes less expensive than surgery or other alternatives.
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What are uterine fibroids? |
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Uterine fibroids are the most common tumors of the female genital tract. You might hear them referred to as "fibroids" or by several other names, including leiomyoma, leiomyomata, myoma and fibromyoma. Fibroids are noncancerous (benign) growths that develop in the muscular wall of the uterus. Uterine fibroids are very common, although often they are very small and cause no problems. From 20 - 40 percent of women age 35 and older have uterine fibroids of a significant size. African-American women are at a higher risk: as many as 50 percent have fibroids of a significant size. While fibroids do not always cause symptoms, their size and location can lead to problems for some women, including pain and heavy bleeding.
Fibroid tumors may start in women when they are in their 20s, however, most women do not begin to have symptoms until they are in their late 30s or 40s. Physicians are not able to predict if a fibroid will grow or cause symptoms.
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The exact causes for fibroid development are unclear, but researchers have linked them to both a genetic predisposition and a subsequent development of susceptibility to hormone stimulation. Women may have a genetic predisposition to fibroid development and then subsequently develop factors that allow fibroids to grow under the influence of a number of hormones. This would explain why certain ethnic groups or racial groups are more likely to develop fibroids and also why there tends to be genetic predisposition in some families.
Fibroids range greatly in size from very tiny to the size of a cantaloupe or larger. In some cases, they can cause the uterus to grow in the size of a five-month pregnancy or more. Fibroids may be located in various parts of the uterus. In most cases, there is more than one fibroid in the uterus. There are three primary types of uterine fibroids.
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Subserosal fibroids,which develop under the outside covering of the uterus and expand outward through the wall, giving the uterus a knobby appearance. They typically do not affect a woman's menstrual flow, but can cause pelvic pain, back pain and generalized pressure. The subserosal fibroid can develop a stalk or stem-like base, making it difficult to distinguish from an ovarian mass. These are called pedunculated. The correct diagnosis can be made with either an ultrasound or magnetic resonance (MR) exam. |
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Intramural fibroids, which develop within the uterus and expand inward, increasing the size of the uterus, and making it feel larger than normal in a gynecologic internal exam. These are the most common fibroids. Intramural fibroids can result in heavier menstrual bleeding and pelvic pain, back pain or the generalized pressure that many women experience. |
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Submucosal fibroids, which are just under the lining of the uterus. These are the least common fibroids, but they tend to cause the most problems. Even a very small submucosal fibroid can cause heavy bleeding - gushing, very heavy and prolonged periods. |
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Most fibroids don't cause symptoms. In fact, only 10 percent to 20 percent of women who have fibroids ever require treatment. Depending on location, size and number of fibroids, a woman might experience the following: |
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Heavy, prolonged menstrual periods and unusual monthly bleeding, sometimes clots.
Anemia
Pelvic pain
Pelvic pressure or heaviness caused by mass of the fibroids pressing on nearby structures
Pain in the back or legs as the fibroids press on nerves that supply the pelvis and legs
Pain during sexual intercourse
Bladder pressure leading to a constant urge to urinate
Pressure on the bowel, leading to constipation and bloating
Abnormally enlarged abdomen
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If you are experiencing these types of symptoms, consult with your personal physician. |
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Dr. Rachel Oser
is a cum laude graduate of Dartmouth College in Hanover, New Hampshire. She attended the Indiana University School of Medicine graduating in 1990 and did her Radiology residency and Interventional Radiology fellowship at the Mallinckrodt Institute of Radiology (associated with Washington University) in St. Louis, Missouri. She joined the UAB faculty in 1995 and is currently a tenured Associate Professor of Radiology. She has board certification from the American Board of Radiology in Diagnostic Radiology, as well as a certificate of added qualification in Vascular and Interventional Radiology. |
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How are uterine fibroids diagnosed? |
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Typically, fibroids are first diagnosed during a gynecologic internal examination. Your doctor will conduct a pelvic exam to feel if your uterus is enlarged. The presence of fibroids is most often confirmed by an abdominal ultrasound. Fibroids also can be confirmed using magnetic resonance (MR) and computed tomography (CT) imaging techniques.
The presence of fibroids is most often confirmed by an abdominal ultrasound. This is a painless procedure in which a radiologist or technician moves an instrument (transducer/receiver) about the size and shape of a computer mouse across the outside surface of the abdomen. Sound waves are transmitted through the skin and allow the technician to "see" the size, shape and texture of the uterus. A picture is displayed on a computer screen as the radiologist or technician takes the ultrasound.
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In some cases, a transvaginal ultrasound may be necessary. The radiologist inserts an ultrasound probe into the vagina so the inside of the uterus can be seen even more clearly than with the abdominal procedure. There is generally little if any discomfort associated with this procedure
Fibroids also can be confirmed using magnetic resonance (MR) imaging or computed tomography (CT). MR and CT also are painless diagnostic tests that can give accurate and clear information on the presence of fibroids.
Diagnostic hysteroscopy also is an option, particularly to evaluate the presence of submucosal fibroids. A long, thin probe-like instrument is passed through the vagina and cervix into the uterus, where the physician can check for growths and take samples of tissue. The lighted hysteroscope illuminates the uterus. This procedure, which can cause some discomfort, is generally performed by a gynecologist, and can be done without anesthesia or with a local anesthetic in an office.
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Uterine Fibroid Treatment Options |
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Appropriate treatment depends on the size and location of the fibroids, as well as the severity of symptoms. If a woman is not experiencing symptoms, her doctor will most likely suggest "watchful waiting" checking the fibroid at annual gynecologic examinations and monitoring for symptoms.
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If symptoms develop, there are a number of treatment options:
Drug therapy, including non-steroidal anti-inflammatory drugs (NSAIDs), birth-control pills and hormone therapy;
Uterine fibroid embolization, a non-surgical treatment that causes the fibroid to shrink.
Surgical treatments, including myomectomy (surgical removal of the fibroids) and hysterectomy (surgical removal of the uterus).
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Treatment Option: Drug Therapy |
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Drug therapy is usually tried first. This might include non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin) or naproxen sodium (Naprosyn), birth-control pills, and hormone therapy.
In some patients, symptoms are controlled with these treatments and no other therapy is required. However, some hormone therapies can have risks and side effects (menopausal symptoms, erratic or no menstruation, bloating, moodiness) when used long-term, and generally are used temporarily.
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A newer group of drugs being used for fibroids are hormones known as GnRH analogues, which are administered by injection by the gynecologist. These synthetic (man-made) hormones act like the hormones that are naturally produced by the body and reduce the level of estrogen. The result is reduced blood flow to the uterus and, therefore, to the fibroids, decreasing the size of both. Some physicians recommend these hormones prior to surgery to reduce the size of the fibroids and make them easier to remove. The effectiveness of the hormones is considered temporary as studies show that when the therapy is stopped, fibroids regrow to their original size in four to six months. The GnRH hormones also may cause side effects that mimic menopause, including hot flashes, vaginal dryness, mood swings and a decrease in bone density (osteoporosis).
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Uterine Fibroid Embolization |
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Known medically as uterine artery embolization, this approach to the treatment of fibroids blocks the arteries that supply blood to the fibroids causing them to shrink. It is a minimally-invasive procedure, which means it requires only a tiny nick in the skin, and is performed while the patient is conscious but sedated - drowsy and feeling no pain.
Fibroid embolization is performed by an interventional radiologist, a physician who is specially trained to perform this and other minimally-invasive procedures.
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The interventional radiologist makes a small nick in the skin (less than one-quarter of an inch) in the groin to access the femoral artery, and inserts a tiny tube (catheter--like a piece of spaghetti) into the artery. Local anesthesia is used so the needle puncture is not painful. The catheter is guided through artery to the uterus while the interventional radiologist guides the process of the procedure using a moving X-ray (flouroscopy).
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The interventional radiologist injects tiny plastic particles the size of grains of sand into the artery that is supplying blood to the fibroid tumor. This stops the blood flow to the fibroid and causes the tumor (or tumors) to shrink. The artery on the other side of the uterus is then treated. |
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The skin puncture where the catheter was inserted is cleaned and covered with a bandage.
Fibroid embolization usually requires a hospital stay of one night. Pain-killing medications and drugs that control swelling typically are prescribed following the procedure to treat cramping and pain. Fever sometimes occurs after embolization and is usually treated with acetaminophen. Many women resume light activities in a few days and the majority of women are able to return to normal activities within one to two weeks.
While embolization to treat uterine fibroids has been performed since 1995, embolization of arteries in the uterus is not new. It has been used successfully by interventional radiologists for more than 20 years to treat heavy bleeding after childbirth.
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Expected Results |
FDA Approval |
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Fibroid embolization usually requires a hospital stay of one night. Pain-killing medications and drugs that control swelling typically are prescribed following the procedure to treat cramping and pain. Many women resume light activities in a few days and the majority of women are able to return to normal activities within seven to 10 days.
On average, 90 percent of women who had the procedure experience significant or total relief of heavy bleeding. The procedure is about 85 percent effective for pain.
The procedure is effective for multiple fibroids and large fibroids.
Recurrence of treated fibroids is very rare. Short and mid-term data show UFE to be very effective with a very low rate of recurrence. Long-term (10 year) data is ongoing and not yet available, but in one study in which patients were followed for six years, no fibroid that had been embolized regrew.
For additional research information, review our UFE bibliography.
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The FDA does not regulate the practice of medicine, but it does approve devices and medications. All devices, equipment and medications used for fibroid embolization are approved by the FDA for use in people.
Many women wonder about the safety of leaving plastic particles in the body. It is reassuring to know that the particles most commonly used in UFE have been available with FDA approval for over 20 years. During that time, they have been used in thousands of patients without long-term complications.
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Fertility |
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There have been numerous reports of pregnancies following uterine fibroid embolization, however prospective studies are needed to determine the effects of uterine fibroid embolization (UFE) on the ability of a woman to have children. One study comparing the fertility of women who had uterine fibroid embolization with those who had myomectomy showed similar numbers of successful pregnancies.11 However, this study has not yet been confirmed by other investigators.
Less than 2 percent of patients have entered menopause as a result of UFE. This is more likely to occur if the woman is in her mid-forties or older and is already nearing menopause
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Side Effects/Complications |
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Fibroid embolization is considered to be very safe, however, there are some associated risks, as there are wtih almost any medical procedure. Most women experience moderate to severe pain and cramping in the first several hours following the procedure. Some experience nausea and fever. These symptoms can be controlled with appropriate medications. A small number of patients have experienced infection, which usually can be controlled with antibiotics. It also has been reported that there is a 1 percent chance of injury to the uterus, potentially leading to hysterectomy. There is also a small risk of developing deep venous thrombosis (blood clots in the veins of the legs) or pulmonary embolism (sending a blood clot to the lungs) after the procedure. This can occur after any surgical procedure as well. These complication rates are lower than those of hysterectomy and myomectomy. |
A small number of patients have entered into menopuase after embolization. This is more likely to occur if the woman is in her mid-forties or older, and is already nearing menopause.
Myomectomy and hysterectomy also carry risks, including infection and bleeding leading to transfusion. Patients who undergo myomectomy may develop adhesions causing tissue and organs in the abdomen to fuse together, which can lead to infertility. In addition, the recovery time is much longer for abdominal myomectomy, generally one to two months.
You should talk to your doctor about possible risks of any procedure you may choose.
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Insurance - Most insurance companies pay for fibroid embolization. You will want to talk with your interventional radiologist about this before your procedure. |
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Surgical Treatments: Myomectomy |
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Myomectomy is a surgical procedure that removes visible fibroids from the uterine wall. Myomectomy, like UFE, leaves the uterus in place and may, therefore, preserve the woman's ability to have children. There are several ways to perform myomectomy, including hysteroscopic myomectomy, laparoscopic myomectomy and abdominal myomectomy.
While myomectomy is successful in controlling symptoms about 80 percent of the time, the more fibroids there are in a patient's uterus, the less successful the surgery generally is. In addition, fibroids grow back several years after myomectomy in 10 percent to 30 percent of cases.
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Hysteroscopic Myomectomy: Hysteroscopic myomectomy is used only for fibroids that are just under the lining of the uterus and that protrude into the uterine cavity. There is no need for a surgical incision. The doctor inserts a flexible scope (hysteroscope) into the uterus through the vagina and cervix and removes the fibroids using special surgical tools fitted to the scope. Usually this is an outpatient procedure performed while the patient is under anesthesia and not conscious. |
Laparoscopic Myomectomy: Laparoscopic myomectomy may be used if the fibroid is on the outside of the uterus. Small incisions are made so the doctor can insert a probe with a tiny camera attached and another probe fitted with surgical instruments inside the abdominal cavity and remove the tumors. It is performed while the patient is under general anesthesia and not conscious. The average recovery time is about two weeks. |
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Abdominal Myomectomy: This is a surgical procedure, in which an incision is made in the abdomen to access the uterus, and another incision is made in the uterus to remove the tumor. Once the fibroids are removed, the uterus is stitched closed. The patient is given general anesthesia and is not conscious for this procedure, which requires a several-day hospital stay. Typical recovery is four to six weeks. |
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Surgical Treatments: Hysterectomy |
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Approximately one-third of the more than half-million hysterectomies performed in the United States each year are due to fibroids.
In a hysterectomy, the uterus is removed in an open surgical procedure. This operation is considered major surgery and is performed while the patient is under general anesthesia. It requires 3 to 4 days of hospitalization and the average recovery period is about six weeks. Some women are candidates for a newer, laparoscopic procedure. The recovery time for this procedure is considerably shorter.
Hysterectomy is the most common current therapy for women who have fibroids. It is typically performed in women who have completed their childbearing years or who understand that after the procedure, they cannot become pregnant.
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Links |
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Ask4UFE.com |
Society of Interventional Radiology Website |
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Fibroids1.com |
UAB Radiology |
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4/12/05 |
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